1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

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Chemical Name:1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate
CAS No.:1417736-31-2
Molecular Formula:C₂HF₃O₂*C₁₉H₂₀F₂N₄O₂
Molecular Weight:488.414
Hs Code.:

Synonyms:1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

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Chemical Property of 1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

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Technology Process of 1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

There total 5 articles about 1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1417736-43-6
[2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

: 1417736-87-8
1-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)cyclohexanol

: 76-05-1
trifluoroacetic acid

: 1417736-31-2
1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

Guidance literature:: [2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol; 1-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)cyclohexanol; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1417736-86-7
1-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)cyclohexanol

: 1417736-31-2
1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 1 h / -20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1417736-31-2
1-{4-amino-5-[3 ,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

1.3: 16 h / 20 °C

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 1 h / -20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;