3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Base Information

Chemical Name:3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid
CAS No.:88208-17-7
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Suppliers and Price of 3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

There total 10 articles about 3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 56-45-1,83245-15-2
L-serin

: 15903-94-3
6-benzyloxy-1H-indole

: 108-24-7
acetic anhydride

: 88208-17-7
3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Guidance literature:: L-serin; acetic anhydride; With acetic acid; at 20 ℃; for 16h; Inert atmosphere;

6-benzyloxy-1H-indole; at 75 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201914620

Reference yield:

: 108-24-7
acetic anhydride

: 67607-63-0
6-benzyloxy-DL-tryptophan

: 88208-17-7
3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Guidance literature:: With sodium hydroxide; at 40 ℃; for 2h;
DOI:10.1016/0031-9422(83)85048-1

Reference yield:

: (E)-2-Azido-3-(4-benzyloxy-phenyl)-acrylic acid ethyl ester

: 88208-17-7
3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / xylene / Heating

2: 91 percent / aq. NaOH / ethanol / Heating

3: 82 percent / Cu; quinoline / Heating

4: 91 percent / CH₃COOH

5: NaOH / toluene / Heating

6: aq. NaOH / Heating

7: H₂O / Heating

With quinoline; sodium hydroxide; copper; acetic acid; In ethanol; water; toluene; xylene; 4: Mannich reaction;
DOI:10.1016/j.bmcl.2006.06.093