3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene

Base Information

• Chemical Name: 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene
• CAS No.: 913290-01-4
• Molecular Formula: C₁₇H₂₁F₂NO₃
• Molecular Weight: 325.355

Synonyms:3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene

Chemical Property of 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene

Chemical Property:

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Technology Process of 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene

There total 2 articles about 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

ethyl 8-chloro-7,7-difluoro-8-(4-methoxyphenylimino)-octanoate → 3,3-Difluoro-2-[(Z)-4-methoxy-phenylimino]-cycloheptanecarboxylic acid ethyl ester + 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene (913290-01-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1021/ol061892w

Reference yield:

ethyl 8-chloro-7,7-difluoro-8-(4-methoxyphenylimino)-2-octenoate → 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cycloheptene (913290-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / hydrogen / Pd/C / ethyl acetate / 24 h / 25 °C / 3040 Torr

2: 24 percent / LDA / tetrahydrofuran; hexane / 1 h / -78 °C

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate; 2: Dieckmann condensation;

DOI:10.1021/ol061892w

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