2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide
CAS No.:1352619-72-7
Molecular Formula:C₃₂H₂₆F₄N₆O₄
Molecular Weight:634.59
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

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Chemical Property of 2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

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Technology Process of 2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

There total 5 articles about 2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352621-30-7
[4-bromo-3-(trifluoromethoxy)phenyl](morpholin-4-yl)methanone

: 1352620-72-4
N-[4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-2-(4-fluorophenyl)-acetamide

: 1352619-72-7
2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Guidance literature:: With potassium phosphate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct; XPhos; In 1-methyl-pyrrolidin-2-one; toluene; at 20 ℃; for 4.08333h; Inert atmosphere; Reflux;

Reference yield:

: 1008769-87-6
4-bromo-3-(trifluoromethoxy)benzoic acid

: 1352619-72-7
2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

2: potassium phosphate / XPhos; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct / toluene; 1-methyl-pyrrolidin-2-one / 4.08 h / 20 °C / Inert atmosphere; Reflux

With potassium phosphate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct; XPhos; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; toluene;

Reference yield:

: 175278-22-5
4-amino-3-(trifluoromethoxy)benzoic acid

: 1352619-72-7
2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 5 °C

2.2: 1.08 h

3.1: sodium hydroxide; ethanol / 2 h / 20 °C

3.2: pH 3

4.1: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: potassium phosphate / XPhos; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct / toluene; 1-methyl-pyrrolidin-2-one / 4.08 h / 20 °C / Inert atmosphere; Reflux

With potassium phosphate; thionyl chloride; ethanol; hydrogen bromide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; sodium nitrite; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct; XPhos; In 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; toluene;