trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

Base Information

Chemical Name:trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one
CAS No.:79952-70-8
Molecular Formula:C₁₉H₂₄F₃NO₆
Molecular Weight:419.398
Hs Code.:

Synonyms:trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

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Chemical Property of trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

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Technology Process of trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

There total 5 articles about trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 72447-85-9,72496-42-5,72843-53-9,72843-54-0,73890-29-6,73890-30-9,74164-94-6,74164-95-7,78088-39-8,79299-24-4,79952-68-4,81076-43-9
(4S)-<(2',2'-dimethoxy)ethyl>-(3R)-<(1'S)-hydroxyethyl>azetidin-2-one

: 79952-70-8
trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

Guidance literature:: With dmap; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)91426-7

Reference yield:

: 92175-00-3,104154-88-3,104154-89-4,104154-90-7
(4S)-(2',2'-dimethoxyethyl)-(3R)-<(1'S)-hydroxyethyl>-1-<(1'S)-phenylethyl>azetidin-2-one

: 79952-70-8
trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Na, EtOH / liquid ammonia; tetrahydrofuran / 0.17 h / -78 °C

2: 85 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; ethanol; sodium; In tetrahydrofuran; dichloromethane; ammonia;
DOI:10.1016/S0040-4020(01)91426-7

Reference yield:

: 104154-86-1
(4R)-(2',2'-dimethoxyethyl)-3(S)-(2'-propenyl)-1-<(1'S)-phenylethyl>azetidin-2-one

: 79952-70-8
trans-4-(2,2-dimethoxyethyl)-3-<(S)-α-methoxy-α-trifluoromethylphenylacetyloxyethyl>azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / O₃, Me₂S / CH₂Cl₂; methanol / 1.) -78 deg C; 2.) r.t., 2 h

2: 85 percent / KI, K-Selectride / diethyl ether; tetrahydrofuran / 0.75 h / Ambient temperature

3: 100 percent / Na, EtOH / liquid ammonia; tetrahydrofuran / 0.17 h / -78 °C

4: 85 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; dimethylsulfide; ethanol; sodium; potassium tri-sec-butyl-borohydride; ozone; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ammonia;
DOI:10.1016/S0040-4020(01)91426-7