2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile

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Chemical Name:2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile
CAS No.:1209963-19-8
Molecular Formula:C₂₂H₂₁N₃O₃
Molecular Weight:375.427
Hs Code.:

Synonyms:2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile

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Chemical Property of 2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile

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Technology Process of 2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile

There total 1 articles about 2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 73831-13-7
4-cyano-3-methylbenzoic acid

: 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one

: 1209963-19-8
2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 14h;
DOI:10.1021/jm901084f

Reference yield: 55.0%

: 1209963-19-8
2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile

: 1209963-23-4
1-{2-methyl-4-[(4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl)carbonyl]phenyl}methanamine

Guidance literature:: 2-methyl-4-{[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]carbonyl}benzonitrile; With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; Inert atmosphere;

With potassium hydrogensulfate; In methanol; water;
DOI:10.1021/jm901084f