N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

Base Information

Chemical Name:N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide
CAS No.:1252657-23-0
Molecular Formula:C₂₇H₃₇N₃O₃S
Molecular Weight:483.675
Hs Code.:

Synonyms:N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

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Chemical Property of N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

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Technology Process of N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

There total 3 articles about N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252658-14-2
C₃₃H₄₀N₄O₇S₂

: 1252657-23-0
N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

Guidance literature:: C₃₃H₄₀N₄O₇S₂; With lithium hydroxide monohydrate; mercaptoacetic acid; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 1252657-23-0
N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

3: mercaptoacetic acid; lithium hydroxide monohydrate / N,N-dimethyl-formamide / 4 h / 40 °C

With lithium hydroxide monohydrate; potassium carbonate; mercaptoacetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1190044-96-2
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-nitrobenzenesulfonamide

: 1252655-94-9
1-(2-tert-butylphenyl)-4-{[4-(chloromethyl)phenyl]carbonyl}piperazine

: 1252657-23-0
N-(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}benzyl)tetrahydro-2H-thiopyran-4-amine 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

2: mercaptoacetic acid; lithium hydroxide monohydrate / N,N-dimethyl-formamide / 4 h / 40 °C

With lithium hydroxide monohydrate; potassium carbonate; mercaptoacetic acid; In N,N-dimethyl-formamide;