5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

Base Information

Chemical Name:5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine
CAS No.:1380089-05-3
Molecular Formula:C₂₅H₁₉FN₄O
Molecular Weight:410.45
Hs Code.:

Synonyms:5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

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Chemical Property of 5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

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Technology Process of 5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

There total 5 articles about 5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.3%

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1380090-15-2
8-chloro-1-methylspiro[benzo[e]isoxazolo[5,4-c]azepine-4,1'-cyclopropan]-6(5H)-one

: 1380089-05-3
5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

Guidance literature:: With potassium dihydrogenphosphate; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; at 20 - 100 ℃; for 27h; Evacuated; Inert atmosphere;

Reference yield:

: 1380090-11-8
tert-butyl (1-(3-methyl-4-(4,4,5,5-tetramethyl1,3,2-dioxaborolan-2-yl)isoxazol-5-yl)cyclopropyl)carbamate

: 1380089-05-3
5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium dihydrogenphosphate / 1,4-dioxane; methanol / 4 h / 80 °C / Inert atmosphere; Sealed vial

2: hydrogenchloride / methanol / 6 h / 20 °C

3: isopropylmagnesium bromide / hydrogenchloride / 0.25 h / 20 °C

4: water; potassium dihydrogenphosphate / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 27 h / 20 - 100 °C / Evacuated; Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; water; isopropylmagnesium bromide; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; methanol;

Reference yield:

: 1380090-13-0
methyl 2-(5-(1-((tert-butoxycarbonyl)amino)cyclopropyl)-3-methylisoxazol-4-yl)-5-chlorobenzoate

: 1380089-05-3
5-(6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropan]-8-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 6 h / 20 °C

2: isopropylmagnesium bromide / hydrogenchloride / 0.25 h / 20 °C

3: water; potassium dihydrogenphosphate / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 27 h / 20 - 100 °C / Evacuated; Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; water; isopropylmagnesium bromide; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; methanol;