Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

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Chemical Name:Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester
CAS No.:495394-79-1
Molecular Formula:C₁₆H₁₉FO₅
Molecular Weight:310.322
Hs Code.:

Synonyms:Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

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Chemical Property of Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

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Technology Process of Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

There total 7 articles about Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (E)-(S)-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-fluoro-1-formyl-allyl ester

: 495394-79-1
Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; water; at 4 ℃; for 0.5h;
DOI:10.1016/S0957-4166(02)00438-X

Reference yield:

: 147410-74-0
(E)/(Z)-ethyl 3-[(S)-2,2-dimethyl-(1,3)-dioxolan-4-yl]-2-fluoroacrylate

: 495394-79-1
Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / DIBAL-H / diethyl ether; hexane / 1.5 h / -78 °C

2: 95.4 percent / tetrahydrofuran / 1 h / -78 °C

3: 10.43 g / pyridine / CH₂Cl₂ / 1 h / 0 °C

4: OsO₄; 4-methylmorpholine N-oxide / acetone; H₂O / 1 h / 20 °C

5: NaIO₄ / ethanol; H₂O / 0.75 h / 20 °C

6: 4.97 g / NaBH₄ / ethanol; H₂O / 0.5 h / 4 °C

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; acetone;
DOI:10.1016/S0957-4166(02)00438-X

Reference yield:

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 495394-79-1
Benzoic acid (E)-(S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-fluoro-2-hydroxy-but-3-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 97.9 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 81 percent / DIBAL-H / diethyl ether; hexane / 1.5 h / -78 °C

3.1: 95.4 percent / tetrahydrofuran / 1 h / -78 °C

4.1: 10.43 g / pyridine / CH₂Cl₂ / 1 h / 0 °C

5.1: OsO₄; 4-methylmorpholine N-oxide / acetone; H₂O / 1 h / 20 °C

6.1: NaIO₄ / ethanol; H₂O / 0.75 h / 20 °C

7.1: 4.97 g / NaBH₄ / ethanol; H₂O / 0.5 h / 4 °C

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hexamethyldisilazane; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; acetone;
DOI:10.1016/S0957-4166(02)00438-X