(S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

Base Information

Chemical Name:(S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester
CAS No.:1290050-34-8
Molecular Formula:C₂₃H₃₂N₂O₇
Molecular Weight:448.516
Hs Code.:

Synonyms:(S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

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Chemical Property of (S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

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Technology Process of (S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

There total 6 articles about (S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290050-70-2
(2S,5RS)-4-(3-tert-butoxycarbonyl-propyl)-5-carbamoyl-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 1290050-34-8
(S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

Guidance literature:: (2S,5RS)-4-(3-tert-butoxycarbonyl-propyl)-5-carbamoyl-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester; With acetic anhydride; acetic acid; sodium nitrite; at 0 ℃; for 16h;

With lithium hydroxide monohydrate; In tetrahydrofuran; water; for 16h;

diazomethyl-trimethyl-silane; In methanol; diethyl ether; dichloromethane; for 0.25h;

Reference yield:

: 127119-10-2
(S)-2-(2,2-dimethoxy-ethylamino)-propionic acid methyl ester

: 1290050-34-8
(S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water; acetone / 2 h / 0 °C

2.1: water; pyridinium p-toluenesulfonate / butanone / 16 h / Reflux

3.1: zinc(II) iodide / dichloromethane / 3 h

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h

4.2: 2 h

5.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide

6.1: acetic anhydride; acetic acid; sodium nitrite / 16 h / 0 °C

6.2: 16 h

6.3: 0.25 h

With lithium hydroxide monohydrate; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; zinc(II) iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetone; butanone;

Reference yield:

: 1205543-11-8
(S)-2-[benzyloxycarbonyl-(2,2-dimethoxy-ethyl)-amino]-propionic acid methyl ester

: 1290050-34-8
(S)-4-(3-tert-butoxycarbonyl-propyl)-6-methyl-5-oxo-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; pyridinium p-toluenesulfonate / butanone / 16 h / Reflux

2.1: zinc(II) iodide / dichloromethane / 3 h

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h

3.2: 2 h

4.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide

5.1: acetic anhydride; acetic acid; sodium nitrite / 16 h / 0 °C

5.2: 16 h

5.3: 0.25 h

With lithium hydroxide monohydrate; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; acetic anhydride; potassium carbonate; acetic acid; zinc(II) iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; butanone;