tert-butyl 2-bromo-5-(trifluoromethyl)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 2-bromo-5-(trifluoromethyl)phenylcarbamate
• CAS No.: 384793-21-9
• Molecular Formula: C₁₂H₁₃BrF₃NO₂
• Molecular Weight: 340.14
• Mol file: 384793-21-9.mol

Synonyms:(2-bromo-5-trifluoromethylphenyl)-carbamic acid tert-butyl ester

Chemical Property of tert-butyl 2-bromo-5-(trifluoromethyl)phenylcarbamate

Chemical Property:

Purity/Quality:

tert-butyl2-bromo-5-(trifluoromethyl)phenylcarbamate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-bromo-5-(trifluoromethyl)phenylcarbamate

There total 4 articles about tert-butyl 2-bromo-5-(trifluoromethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N,N'-bis(tert-butyloxycarbonyl)-2-bromo-5-trifluoromethylaniline (880384-45-2) → (2-bromo-5-trifluoromethylphenyl)-carbamic acid tert-butyl ester (384793-21-9)

Guidance literature:

With methanol; potassium carbonate; for 2h; Heating / reflux;

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-Bromo-5-trifluoromethylaniline (454-79-5) → (2-bromo-5-trifluoromethylphenyl)-carbamic acid tert-butyl ester (384793-21-9)

Guidance literature:

di-tert-butyl dicarbonate; 2-Bromo-5-trifluoromethylaniline; With dmap; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;

With potassium carbonate; In methanol; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/jo802604g

Reference yield: 77.0%

t-butyl<3-(trifluoromethyl)phenyl>-carbamate (109134-07-8) → (2-bromo-5-trifluoromethylphenyl)-carbamic acid tert-butyl ester (384793-21-9)

Guidance literature:

t-butyl<3-(trifluoromethyl)phenyl>-carbamate; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -50 ℃; for 3h;

With carbon tetrabromide; In tetrahydrofuran; pentane; at -75 ℃; Further stages.;

DOI:10.1016/j.jfluchem.2007.09.003

upstream raw materials:

N,N'-bis(tert-butyloxycarbonyl)-2-bromo-5-trifluoromethylaniline

2-Bromo-5-trifluoromethylaniline

t-butyl<3-(trifluoromethyl)phenyl>-carbamate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl N-[2-bromo-5-(trifluoromethyl)phenyl]-N-(prop-2-ynyl)carbamate

tert-butyl (2-bromo-5-trifluoromethylphenyl)(2-methylallyl)carbamate

tert-butyl 2-bromo-5-(trifluoromethyl)phenyl(((chloromethyl)dimethylgermyl)methyl)carbamate

N-(2-bromo-5-trifluoromethylphenyl)-N-tert-butoxycarbonylphenylethynylamine