tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane

Base Information

• Chemical Name: tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane
• CAS No.: 1227307-28-9
• Molecular Formula: C₂₆H₃₄O₂Si
• Molecular Weight: 406.64

Synonyms:tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane

Chemical Property of tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane

There total 2 articles about tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl-(2-((2S,4S,6S)-4-iodo-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy)diphenylsilane (1227307-12-1) → tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane (1227307-28-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 60 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol100665m

Reference yield:

1-(((S)-1-((tert-butyldiphenylsilyl)oxy)hex-5-en-3-yl)oxy)but-2-yn-1-yl acetate → tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane (1227307-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine; trimethylsilyl iodide / dichloromethane / 0.92 h / -19 - 20 °C

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / 60 °C

With 2,6-dimethylpyridine; 2,2'-azobis(isobutyronitrile); trimethylsilyl iodide; tri-n-butyl-tin hydride; In dichloromethane; toluene;

DOI:10.1002/chem.201202553

Reference yield: 74.0%

tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane (1227307-28-9) + tri-n-butyl-tin hydride (688-73-3) → C38H62O2SiSn (1227307-35-8)

Guidance literature:

With n-butyllithium; copper(l) cyanide; In tetrahydrofuran; hexane; at -78 - -10 ℃;

DOI:10.1002/chem.201202553

upstream raw materials:

tert-butyl-(2-((2S,4S,6S)-4-iodo-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy)diphenylsilane

Downstream raw materials:

tert-butyl-(2-((2R,6S)-6-((E)-2-iodoprop-1-enyl)tetrahydro-2H-pyran-2-yl)ethoxy-)diphenylsilane

(S,E)-5-((2S,6R)-6-(2-(tert-butyldiphenylsilyloxy-)ethyl-)tetrahydro-2H-pyran-2-yl)-1-(4-methoxybenzyloxy)-4-methylpent-4-en-2-ol

(2E,4Z)-((S,E)-5-((2S,6R)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)tetrahydro-2H-pyran-2-yl)-1-(4-methoxybenzyloxy)-4-methylpent-4-en-2-yl) 7-(tert-butyl dimethyl silyloxy)-8-(diethoxyphosphoryl)-5-methylocta-2,4-dienoate

(2E,4Z)-((2S,E)-5-((2S,6R)-6-(2-hydroxyethyl)tetrahydro-2H-pyran-2-yl)-1-(4-methoxybenzyloxy)-4-methylpent-4-en-2-yl) 8-(diethoxyphosphoryl)-7-hydroxy-5-methylocta-2,4-dienoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1227307-28-9 tert-butyldiphenyl(2-((2R,6S)-6-(prop-1-ynyl)tetrahydro-2H-pyran-2-yl)ethoxy-)silane

Send

Send

Metric Ton KG G Pound L ML

Send

Send