ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Base Information

Chemical Name:ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate
CAS No.:1427549-59-4
Molecular Formula:C₃₅H₃₈FN₅O₄
Molecular Weight:611.716
Hs Code.:

ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Synonyms:ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

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Chemical Property of ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

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Technology Process of ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

There total 8 articles about ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 491585-44-5
(E)-3-{4-[(1-aminocyclobutanecarbonyl)amino]phenyl}-acrylic acid ethyl ester

: 1427549-95-8
3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-7-carboxylic acid

: 1427549-59-4
ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Guidance literature:: With ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

Reference yield:

: 1427549-91-4
ethyl 3-cyclohexyl-2-(4-fluorophenyl)-1H-imidazo[1,2-b]pyrazole-7-carboxylate

: 1427549-59-4
ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2: water; lithium hydroxide / tetrahydrofuran; methanol / 6 h / 60 °C

3: ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

With ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1427549-81-2
2-bromo-2-cyclohexyl-1-(4-fluorophenyl)ethanone

: 1427549-59-4
ethyl (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-7-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

1.2: 2 h / 65 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 6 h / 60 °C

4.1: ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

With ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;