3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride

Base Information

• Chemical Name: 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride
• CAS No.: 1417342-72-3
• Molecular Formula: C₁₄H₁₉NO*ClH
• Molecular Weight: 253.772
• Mol file: 1417342-72-3.mol

Synonyms:3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride

Chemical Property of 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride

There total 3 articles about 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 3-cyclopropylmethoxy-3-o-tolylazetidine-1-carboxylate (1417342-71-2) → 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride (1417342-72-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1.5h;

Reference yield:

tert-butyl 3-hydroxy-3-(o-tolyl)azetidine-1-carboxylate (1225439-73-5) → 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride (1417342-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 18 - 23 °C / Large scale

1.2: 1 h / 10 °C / Large scale

2.1: hydrogenchloride / isopropyl alcohol / 60 °C / Large scale

With hydrogenchloride; potassium tert-butylate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/acs.oprd.5b00097

Reference yield:

ortho-tolylmagnesium bromide (932-31-0) → 3-(cyclopropylmethoxy)-3-(o-tolyl)azetidine hydrochloride (1417342-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2-methyltetrahydrofuran / 3 h / -20 °C / Large scale

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 18 - 23 °C / Large scale

2.2: 1 h / 10 °C / Large scale

3.1: hydrogenchloride / isopropyl alcohol / 60 °C / Large scale

With hydrogenchloride; potassium tert-butylate; In 2-methyltetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: |Grignard Reaction;

DOI:10.1021/acs.oprd.5b00097

upstream raw materials:

tert-butyl 3-cyclopropylmethoxy-3-o-tolylazetidine-1-carboxylate

ortho-tolylmagnesium bromide

tert-butyl 3-hydroxy-3-(o-tolyl)azetidine-1-carboxylate

Downstream raw materials:

tert-butyl [(R)-2-(3-cyclopropylmethoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]carbamate