2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

Base Information

Chemical Name:2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester
CAS No.:945460-03-7
Molecular Formula:C₂₃H₂₃FN₄O₃
Molecular Weight:422.459
Hs Code.:

Synonyms:2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

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Chemical Property of 2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

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Technology Process of 2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

There total 2 articles about 2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 52317-97-2
4-fluoro-1-isothiocyanato-2-methylbenzene

: 333458-43-8
2-(4-amino-2-cyano-3-methylaminophenyl)-2-methyl-3-oxobutyric acid ethyl ester

: 945460-03-7
2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

Guidance literature:: 4-fluoro-1-isothiocyanato-2-methylbenzene; 2-(4-amino-2-cyano-3-methylaminophenyl)-2-methyl-3-oxobutyric acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 48h;

With mercury(II) oxide; In tetrahydrofuran; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield: 52.0%

: 52317-97-2
4-fluoro-1-isothiocyanato-2-methylbenzene

: 945460-03-7
2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

Guidance literature:: 2-(4-amino-2-cyano-3-methylaminophenyl)-2-methyl-3-oxobutyric acid ethyl ester; dmap; In tetrahydrofuran;

4-fluoro-1-isothiocyanato-2-methylbenzene; In tetrahydrofuran; at 20 ℃; for 12h;

With mercury(II) oxide; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 89.0%

: 945460-03-7
2-[4-cyano-2-(4-fluoro-2-methyl-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

: 2-(4-fluoro-2-methyl-phenylamino)-1,6,7-trimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one

Guidance literature:: With sulfuric acid; acetic acid; In water; at 20 - 100 ℃; for 19h; Product distribution / selectivity; Heating / reflux;