(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

Base Information

Chemical Name:(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one
CAS No.:1416909-63-1
Molecular Formula:C₂₁H₂₄ClNO₄
Molecular Weight:389.879
Hs Code.:

Synonyms:(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

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Chemical Property of (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

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Technology Process of (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

There total 8 articles about (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1416909-64-2
(S)-1-(4-chloro-phenyl)-6-hydroxy-7-isopropoxy-1,4-dihydro-2H-isoquinolin-3-one

: 6482-24-2
2-Bromoethyl methyl ether

: 1416909-63-1
(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1416909-63-1
(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphoric acid / 2 h / 120 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 55 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 0.17 h / 13 - 170 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

5.1: Chiralpak AS / ethanol; methanol / Resolution of racemate

6.1: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 7 h / 50 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With phosphoric acid; sodium hydride; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 4468-59-1
4-hydroxy-3-methoxyphenylacetonitrile

: 1416909-63-1
(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphoric acid / 2 h / 120 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 55 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 0.17 h / 13 - 170 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

5.1: Chiralpak AS / ethanol; methanol / Resolution of racemate

6.1: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 7 h / 50 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With phosphoric acid; sodium hydride; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil;