(R_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid

Base Information

• Chemical Name: (R_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid
• CAS No.: 202257-45-2
• Molecular Formula: C₁₇H₂₂O₄S
• Molecular Weight: 322.425

Synonyms:(R_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid

Chemical Property of (R_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid

Chemical Property:

Purity/Quality:

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Technology Process of (R_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid

There total 7 articles about (R_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

spiro<4H-3a,6-methano-3H-1,2-benzoxasulfole-2,2'λ4-<5H-1,2>benzoxathiole>-5'-one, 5,6,7,7a-tetrahydro-8,8-dimethyl-, <3R-(2α,3aα,6α,7aβ)> (202257-40-7) → (RS)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid (202257-45-2)

Guidance literature:

With sodium hydroxide; In ethanol; at 0 ℃; for 0.5h;

DOI:10.1021/jo981330t

Reference yield: 88.0%

C17H20O3S (202257-40-7) → (RS)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid (202257-45-2)

Guidance literature:

With sodium hydroxide; at 0 ℃; for 0.5h; Mechanism; also in aq. HCl; var. temp. and reaction time;

DOI:10.1021/ja973039l

Reference yield:

Thiosalicylic acid (147-93-3) → (RS)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid (202257-45-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / NaH / benzene; dimethylformamide / 6 h / 95 °C

2: 96 percent / t-BuOCl, Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3: 98 percent / aq. HCl / ethanol / 48 h / Ambient temperature

4: aq. HCl / ethanol / 5 h / Heating

With hydrogenchloride; tert-butylhypochlorite; sodium hydride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo981330t

upstream raw materials:

C₁₇H₂₀O₃S

(S_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid

spiro<4H-3a,6-methano-3H-1,2-benzoxasulfole-2,2'λ⁴-<5H-1,2>benzoxathiole>-5'-one, 5,6,7,7a-tetrahydro-8,8-dimethyl-, <3R-(2α,3aα,6α,7aβ)>

Thiosalicylic acid

Downstream raw materials:

(S_S)-2-(<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptan-1-yl>methanesulfinyl)benzoic acid

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