Chemical Property of 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Chemical Property:
- Appearance/Colour:White cyrstalline solid
- Vapor Pressure:5.79E-12mmHg at 25°C
- Melting Point:175-176 °C
- Refractive Index:1.675
- Boiling Point:545.7 °C at 760 mmHg
- PKA:4.50±0.30(Predicted)
- Flash Point:283.8 °C
- PSA：69.62000
- Density:1.25 g/cm3
- LogP:4.48870
- Storage Temp.:-20°C Freezer
- Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated)
- XLogP3:3.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:331.17969569
- Heavy Atom Count:25
- Complexity:462
- Purity/Quality:
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99%, *data from raw suppliers
4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo[3,4-d]pyrimidine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)(C)N1C2=NC=NC(=C2C(=N1)CC3=CC=CC4=CC=CC=C43)N
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Description
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.
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Uses
A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase
