N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

Base Information

Chemical Name:N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide
CAS No.:1314890-37-3
Molecular Formula:C₂₄H₂₀F₃N₅O₃S
Molecular Weight:515.516
Hs Code.:

Synonyms:N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

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Chemical Property of N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

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Technology Process of N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

There total 6 articles about N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid

: (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine hydrochloride

: 1314890-37-3
N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 10h;

Reference yield:

: 887579-62-6
5-cyano-3-pyridinecarboxylic acid

: 1314890-37-3
N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium carbonate; 8-quinolinol / ethanol; water / 3 h / Reflux

2: pyridine / 3 h / 65 °C

3: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 10 h / 0 - 20 °C

With 4-methyl-morpholine; 8-quinolinol; hydroxylamine hydrochloride; sodium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In pyridine; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 29681-44-5
5-bromo-3-pyridine carboxylic acid methyl ester

: 1314890-37-3
N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 12 h / 160 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 1 h / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium carbonate; 8-quinolinol / ethanol; water / 3 h / Reflux

4: pyridine / 3 h / 65 °C

5: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 10 h / 0 - 20 °C

With 4-methyl-morpholine; 8-quinolinol; hydroxylamine hydrochloride; water; sodium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; pyridine; ethanol; water; N,N-dimethyl-formamide;