HOMO-L-TYROSINE HBR

Base Information

• Chemical Name: HOMO-L-TYROSINE HBR
• CAS No.: 221243-01-2
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Mol file: 221243-01-2.mol

Synonyms:L-HOMOTYROSINE HYDROBROMIDE;L-HOMOTYROSINE HYDROBROMIDE SALT;H-TYR(NO CH2)-OH HBR;HOMO-TYROSINE HBR;HOMO-TYROSINE HYDROBROMIDE;HOMO-L-TYROSINE HBR;HOMO-L-TYROSINE, HYDROBROMIDE;H-HTY-OH HBR

Chemical Property of HOMO-L-TYROSINE HBR

Chemical Property:

• Melting Point: 217-220 °C
• Boiling Point: 397°Cat760mmHg
• PKA: 2.30±0.10(Predicted)
• Flash Point: 193.9°C
• PSA: 83.55000
• Density: 1.281g/cm³
• LogP: 2.39510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-2-Amino-4-(4-hydroxyphenyl)butanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HOMO-L-TYROSINE HBR

There total 22 articles about HOMO-L-TYROSINE HBR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C13H14F3NO4 (1263096-03-2) → (S)-homotyrosine (221243-01-2,185062-84-4)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 6h;

DOI:10.1016/j.tet.2010.11.047

Reference yield: 73.0%

O-methyl-L-homotyrosine (82311-00-0,82310-97-2) → (S)-homotyrosine (221243-01-2,185062-84-4)

Guidance literature:

With hydrogen iodide; for 15h; Reflux;

DOI:10.1007/s00726-016-2263-7

Reference yield: 45.0%

Acetic acid 4-((3aS,7S)-4-oxo-7-phenyl-hexahydro-isoxazolo[3,2-c][1,4]oxazin-2-yl)-phenyl ester (368875-94-9) → (S)-homotyrosine (221243-01-2,185062-84-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In 1,4-dioxane; trifluoroacetic acid; under 3102.89 Torr;

DOI:10.1016/S0040-4039(01)00821-8

upstream raw materials:

Acetic acid 4-((3aS,7S)-4-oxo-7-phenyl-hexahydro-isoxazolo[3,2-c][1,4]oxazin-2-yl)-phenyl ester

2-Chloroanisole

(S)-4-(3-Chloro-4-methoxy-phenyl)-2-(3-methyl-ureido)-4-oxo-butyric acid

p-acetoxystyrene

Downstream raw materials:

L-homotyrosine methyl ester

4-(4-benzyloxycarbonylamino-phenyl)-2-tert-butoxycarbonylamino-butyric acid methyl ester

L-N^α-(tert-butoxycarbonyl)-4-(N-benzyloxycarbonylamino)-homophenylalanine

4-(3-tert-butoxycarbonylamino-3-methoxycarbonyl-propyl)-benzoic acid

Refernces

• 1、 -. "Method for Preparing Unnatural Amino Acids". Paragraph 0172; 0173; 0203; 0204. . Retrieved 2017/01/09.
• 2、 Okumura, Hilary S.,Philmus, Benjamin,Portmann, Cyril,Hemscheidt, Thomas K.. "Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8". experimental part. p. 172 - 176. Retrieved 2009/06/27.