2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

Base Information

Chemical Name:2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide
CAS No.:1361413-52-6
Molecular Formula:C₂₇H₂₀F₄N₂O₄S₂
Molecular Weight:576.592
Hs Code.:

Synonyms:2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

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Chemical Property of 2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

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Technology Process of 2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

There total 11 articles about 2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1361414-53-0
(2-amino-4-(3-(trifluoromethyl)phenyl)thiazol-5-yl)(3-fluorophenyl) methanone

: 1361413-52-6
2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 36h;

Reference yield:

: 454-92-2
3-(trifluoromethyl)benzoic acid

: 1361413-52-6
2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 2 h / 40 °C

2.1: acetone / 2 h / 0 °C

2.2: 1 h / 0 °C

3.1: N,N-dimethyl-formamide / 1.5 h / 85 °C / Inert atmosphere

4.1: trifluoroacetic acid / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 36 h / 40 °C

With thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 53631-18-8
2-bromo-1-(3-fluorophenyl)ethanone

: 1361413-52-6
2-(4-(ethylsulfonyl)phenyl)-N-(5-(3-fluorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 1.5 h / 85 °C / Inert atmosphere

2: trifluoroacetic acid / 80 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 36 h / 40 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;