8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Base Information

Chemical Name:8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one
CAS No.:1470027-72-5
Molecular Formula:C₂₅H₁₉N₃O₅
Molecular Weight:441.443
Hs Code.:

Synonyms:8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

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Chemical Property of 8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

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Technology Process of 8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

There total 4 articles about 8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 256378-50-4
2-amino-4,5-dihydro-4-(3-nitrophenyl)-5-oxopyrano[3,2-c]chromene-3-carbonitrile

: 1470027-72-5
8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Guidance literature:: With aluminum (III) chloride; In 1,2-dichloro-ethane; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2013.07.045

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1470027-72-5
8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: (2-aminomethyl)phenol moiety on the surface of hydroxyapatite encapsulated maghemite (γ-Fe₂O₃) / water / 0.08 h / Reflux

2: (2-aminomethyl)phenol moiety on the surface of hydroxyapatite encapsulated maghemite (γ-Fe₂O₃) / water / Reflux

3: aluminum (III) chloride / 1,2-dichloro-ethane / 24 h / Inert atmosphere; Reflux

With aluminum (III) chloride; In water; 1,2-dichloro-ethane; 3: |Friedlaender Quinoline Synthesis;
DOI:10.1016/j.ejmech.2013.07.045

Reference yield:

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 1470027-72-5
8-amino-7-(3-nitrophenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: silica sodium carbonate / neat (no solvent) / 110 °C

2: sodium carbonate / dimethyl sulfoxide / 5 h / 100 °C

With sodium carbonate; In dimethyl sulfoxide;
DOI:10.17344/acsi.2020.6266