(R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:(R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester
CAS No.:210549-11-4
Molecular Formula:C₃₂H₄₅N₃O₇
Molecular Weight:583.725
Hs Code.:

Synonyms:(R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

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Chemical Property of (R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

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Technology Process of (R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

There total 10 articles about (R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 210549-10-3
(R)-9-Benzyl-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

: 210549-11-4
(R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: With camphor-10-sulfonic acid; In methanol; for 24h; Ambient temperature;
DOI:10.1002/hlca.19980810541

Reference yield:

: 90914-08-2
N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine

: 210549-11-4
(R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 76 percent / Et₃N / tetrahydrofuran / 36 h / Heating

2: 95 percent / CF₃COOH / CH₂Cl₂ / 2 h / Ambient temperature

3: LiCl / tetrahydrofuran / 240 h / Ambient temperature

4: 77 percent / H₂ / Raney-Ni / ethanol; aq. NH₃ / 3040 Torr / Ambient temperature

5: 80 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 4 h / Ambient temperature

6: 63 percent / (EtO)2POCN, Et₃N / dimethylformamide / 24 h / Ambient temperature

7: 89 percent / (i-Pr)2EtN / tetrahydrofuran / 4 h / Heating

8: 76 percent / NaH, 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / Ambient temperature

9: 69 percent / camphorsulfonic acid / methanol / 24 h / Ambient temperature

With dmap; lithium hydroxide; diethyl cyanophosphonate; camphor-10-sulfonic acid; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; nickel; In tetrahydrofuran; methanol; ammonium hydroxide; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19980810541

Reference yield:

: 90914-11-7
N-[N-(tert-Butoxycarbonyl)-3-aminopropyl]-N-(3-cyanopropyl)benzylamine

: 210549-11-4
(R)-9-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-2-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / CF₃COOH / CH₂Cl₂ / 2 h / Ambient temperature

2: LiCl / tetrahydrofuran / 240 h / Ambient temperature

3: 77 percent / H₂ / Raney-Ni / ethanol; aq. NH₃ / 3040 Torr / Ambient temperature

4: 80 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 4 h / Ambient temperature

5: 63 percent / (EtO)2POCN, Et₃N / dimethylformamide / 24 h / Ambient temperature

6: 89 percent / (i-Pr)2EtN / tetrahydrofuran / 4 h / Heating

7: 76 percent / NaH, 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / Ambient temperature

8: 69 percent / camphorsulfonic acid / methanol / 24 h / Ambient temperature

With dmap; lithium hydroxide; diethyl cyanophosphonate; camphor-10-sulfonic acid; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; nickel; In tetrahydrofuran; methanol; ammonium hydroxide; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19980810541