2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione
CAS No.:1360552-61-9
Molecular Formula:C₃₀H₂₆N₈O₃
Molecular Weight:546.588
Hs Code.:

Synonyms:2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

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Chemical Property of 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

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Technology Process of 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

There total 7 articles about 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 1360549-37-6
5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine

: 1360552-61-9
2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 6952-89-2
(4-bromophenyl)(cyclopropyl)methanone

: 1360552-61-9
2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran; diethyl ether / 2.16 h / -78 - 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

2.2: 2 h / -78 - 20 °C

3.1: carbon dioxide / ethanol / Resolution of racemate

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 24 h / 80 °C

5.1: water; potassium hydroxide; hydroxylamine / 48 h / 85 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 - 50 °C

6.2: 24 h / Reflux

6.3: 2 h / 20 - 90 °C

7.1: caesium carbonate / N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; boron trifluoride diethyl etherate; water; hydroxylamine; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1360551-88-7
2-(4-bromo-phenyl)-2-cyclopropylpropionitrile

: 1360552-61-9
2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon dioxide / ethanol / Resolution of racemate

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 24 h / 80 °C

3.1: water; potassium hydroxide; hydroxylamine / 48 h / 85 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 - 50 °C

4.2: 24 h / Reflux

4.3: 2 h / 20 - 90 °C

5.1: caesium carbonate / N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; water; hydroxylamine; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;