N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

Chemical Name:N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
CAS No.:108782-95-2
Molecular Formula:C₂₉H₄₄N₂O₈Si₂
Molecular Weight:604.848
Hs Code.:

N<SUP>3</SUP>-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Synonyms:N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Suppliers and Price of N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 5 articles about N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-Methyl-benzoic acid 1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

: 108782-95-2
N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: In 1,2-dichloro-ethane; at 60 ℃; for 0.25h;
DOI:10.1055/s-0035-1560264

Reference yield:

: 119694-66-5
4-O-<(2,4,6-triisopropylphenyl)sulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 108782-95-2
N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: 6 percent / conc. aq. NH₃ / dioxane / 4 h / Ambient temperature

2: 1.) Na₂CO₃, tetrabutylammonium bromide / 1.) CH₂Cl₂, H₂O, RT, 45 min, 2.) 1,2-dichloroethane, 60 deg C, 45 min

With ammonium hydroxide; tetrabutylammomium bromide; sodium carbonate; In 1,4-dioxane;
DOI:10.1021/jo00271a015

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 108782-95-2
N³-(4-methylbenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 4-Methyl-benzoic acid 1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

Guidance literature:: With tetrabutylammomium bromide; sodium carbonate; In dichloromethane; water; for 0.75h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jo00271a015