2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
• CAS No.: 218900-62-0
• Molecular Formula: C₃₂H₄₂O₇S
• Molecular Weight: 570.747
• Mol file: 218900-62-0.mol

Synonyms:2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Chemical Property of 2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (218900-42-6) → 2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (218900-62-0)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1135/cccc19981597

Reference yield: 98.0%

toluene-4-sulfonic acid hydrazide (1576-35-8) + 2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (218900-62-0) → 7-oxo-19-(phenylsulfonyl)androst-5-ene-3β,17β-diyl 3-acetate 17-pivalate tosylhydrazone (218900-63-1)

Guidance literature:

In methanol; at 55 ℃; for 14h;

DOI:10.1135/cccc19981597

Reference yield:

2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (218900-62-0) → 2,2-Dimethyl-propionic acid (1S,3aR,7aS)-4-{(S)-2-[(S)-5-acetoxy-2-methylene-cyclohex-(Z)-ylidene]-1-benzenesulfonyl-ethyl}-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-1-yl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / methanol / 14 h / 55 °C

2: 67 percent / LiH / toluene / 0.75 h / Heating

3: benzene; diethyl ether / 0.25 h / 0 °C / Irradiation

With lithium hydride; In methanol; diethyl ether; toluene; benzene;

DOI:10.1135/cccc19981597

upstream raw materials:

2,2-Dimethyl-propionic acid (3S,8S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Downstream raw materials:

7-oxo-19-(phenylsulfonyl)androst-5-ene-3β,17β-diyl 3-acetate 17-pivalate tosylhydrazone

2,2-Dimethyl-propionic acid (3S,9S,10S,13S,14S,17S)-3-acetoxy-10-benzenesulfonylmethyl-13-methyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester