(3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Base Information

• Chemical Name: (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol
• CAS No.: 160309-22-8
• Molecular Formula: C₁₆H₂₅ClO₃
• Molecular Weight: 300.826

Synonyms:(3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Chemical Property of (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

There total 3 articles about (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

cyclohexylmethyl magnesium bromide (35166-78-0) + (1R,4S,5S,6R)-3-chloro-4,5-O-isopropylidene-7-oxabicyclo[4.1.0]hept-2-ene-4,5-diol (138913-30-1) → (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol (160309-22-8)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1021/jo00094a005

Reference yield: 4.0%

(1R,4S,5S,6R)-3-chloro-4,5-O-isopropylidene-7-oxabicyclo[4.1.0]hept-2-ene-4,5-diol (138913-30-1) → (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol (160309-22-8) + (3aS,4R,5R,7aR)-5,7-Bis-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - -40 ℃;

DOI:10.1021/jo00094a005

Reference yield:

diphenylzinc (1078-58-6) + (1R,4S,5S,6R)-3-chloro-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene (160309-17-1) → (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol (160309-22-8) + (1R,2S,5R,6S)-N-(5,6-Isopropylidenedioxy-2,4-diphenylcyclohex-3-enyl)-(4'-methylphenyl)sulfonamide

Guidance literature:

In tetrahydrofuran; diethyl ether; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo00094a005

upstream raw materials:

diphenylzinc

(1R,4S,5S,6R)-3-chloro-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene

cyclohexylmethyl magnesium bromide

(1R,4S,5S,6R)-3-chloro-4,5-O-isopropylidene-7-oxabicyclo[4.1.0]hept-2-ene-4,5-diol

Downstream raw materials:

(3aS,4R,5S,7aR)-5-Cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

(3aR,4S,5R,6S,7R,7aS)-5-Azido-6-cyclohexylmethyl-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-4,7-diol

(3aR,4S,5R,6S,7R,7aS)-5-Amino-6-cyclohexylmethyl-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-4,7-diol

(1aS,2R,3R,3aS,6aR,6bS)-2-Cyclohexylmethyl-5,5-dimethyl-hexahydro-1,4,6-trioxa-cyclopropa[e]inden-3-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 160309-22-8 (3aS,4R,5S,7aS)-7-Chloro-5-cyclohexylmethyl-2,2-dimethyl-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send