Technology Process of Glycine, N-(3-cyanopropyl)-, ethyl ester (9CI)
There total 1 articles about Glycine, N-(3-cyanopropyl)-, ethyl ester (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetonitrile;
for 18h;
Ambient temperature;
DOI:10.1248/cpb.47.11
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 68 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / dimethylformamide / 4 h / Ambient temperature
2: trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
3: triethylamine / CHCl3 / 1 h / 4 °C
4: 46 percent / sodium azide, ammonium chloride / dimethylformamide / 24 h / 100 °C
5: triethylamine / CHCl3 / 2 h / Ambient temperature
6: 1 M aq. NaOH / methanol / 2 h / Ambient temperature
With
4-methyl-morpholine; sodium hydroxide; sodium azide; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.11
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 68 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / dimethylformamide / 4 h / Ambient temperature
2: trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
3: triethylamine / CHCl3 / 1 h / 4 °C
4: 1 M aq. NaOH / methanol / 2 h / Ambient temperature
5: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / dimethylformamide / 12 h / Ambient temperature
6: 45 percent / Dess-Martin periodinane / CH2Cl2 / 1 h
7: 72 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
With
4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.11
