(2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol

Base Information

Chemical Name:(2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol
CAS No.:120341-83-5
Molecular Formula:C₂₇H₃₈O₅Si
Molecular Weight:470.681
Hs Code.:

Synonyms:(2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol

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Chemical Property of (2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol

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Technology Process of (2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol

There total 11 articles about (2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 120341-82-4
(2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-4-(trimethylenedithio)octane-1,2,6,8-tetrol

: 120341-83-5
(2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol

Guidance literature:: With calcium carbonate; methyl iodide; In water; acetonitrile; for 24h; Ambient temperature;
DOI:10.1248/cpb.38.2574

Reference yield: 81.0%

: 120341-82-4,127725-24-0
(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-[2-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-butan-2-ol

: 120341-83-5,127725-23-9
(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-hexan-2-one

Guidance literature:: With MeI-CaCO₃; In water; acetonitrile;
DOI:10.1016/S0040-4039(00)99366-3

Reference yield:

: 125975-53-3,147220-48-2,116996-54-4
(2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol

: 120341-83-5
(2S,6S)-8-(O-tert-butyldiphenylsilyl)-1,2-(O-isopropylidene)-octan-4-one-1,2,6,8-tetrol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 1.6 M n-BuLi in hexane / tetrahydrofuran / 20 h / -20 °C

2: 89 percent / methyl iodide, calcium carbonate / acetonitrile; H₂O / 24 h / Ambient temperature

With n-butyllithium; calcium carbonate; methyl iodide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/S0040-4020(01)89416-3