trans-2(4'-Aminostyryl)thiophene

Base Information

• Chemical Name: trans-2(4'-Aminostyryl)thiophene
• CAS No.: 41839-01-4
• Molecular Formula: C₁₂H₁₁NS
• Molecular Weight: 201.292
• DSSTox Substance ID: DTXSID901274568
• Mol file: 41839-01-4.mol

Synonyms:trans-2(4'-aminostyryl)thiophene;DTXSID901274568;41839-01-4;4-[(1E)-2-(2-Thienyl)ethenyl]benzenamine

Chemical Property of trans-2(4'-Aminostyryl)thiophene

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 201.06122053
• Heavy Atom Count: 14
• Complexity: 195

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CSC(=C1)C=CC2=CC=C(C=C2)N
• Isomeric SMILES: C1=CSC(=C1)/C=C/C2=CC=C(C=C2)N

Technology Process of trans-2(4'-Aminostyryl)thiophene

There total 8 articles about trans-2(4'-Aminostyryl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-[2-(4-nitrophenyl)ethenyl]thiophene (42970-79-6) → (E)-4-(2-(thiophen-2-yl)vinyl)aniline (41839-01-4)

Guidance literature:

With ammonium chloride; zinc; In water; acetone; for 2h; Reflux;

DOI:10.1007/s11696-017-0140-9

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → (E)-4-(2-(thiophen-2-yl)vinyl)aniline (41839-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; piperidine / 8 h / 100 °C

2: iron(II) sulfate; ammonium hydroxide / 3 h / 100 °C

With piperidine; pyridine; ammonium hydroxide; iron(II) sulfate;

DOI:10.1007/s10895-018-2284-6

Reference yield:

(p-nitrobenzyl)triphenylphosphonium bromide (2767-70-6) → (E)-4-(2-(thiophen-2-yl)vinyl)aniline (41839-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane / 1.5 h / 20 °C

2: ammonium chloride; zinc / water; acetone / 2 h / Reflux

With ammonium chloride; sodium hydroxide; zinc; In dichloromethane; water; acetone; 1: |Wittig Olefination;

DOI:10.1007/s11696-017-0140-9

upstream raw materials:

(E)-2-[2-(4-nitrophenyl)ethenyl]thiophene

3-(2-thienyl)acrylic acid

thiophene-2-carbaldehyde

(p-nitrobenzyl)triphenylphosphonium bromide