3-phenyl-2-propynyl ethyl malononitrile

Base Information

• Chemical Name: 3-phenyl-2-propynyl ethyl malononitrile
• CAS No.: 92199-63-8
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.263
• Mol file: 92199-63-8.mol

Synonyms:3-phenyl-2-propynyl ethyl malononitrile

Chemical Property of 3-phenyl-2-propynyl ethyl malononitrile

Chemical Property:

Purity/Quality:

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Technology Process of 3-phenyl-2-propynyl ethyl malononitrile

There total 1 articles about 3-phenyl-2-propynyl ethyl malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Phenylpropargyl aldehyde (2579-22-8) + ethyl 2-cyanoacetate (105-56-6) → 3-phenyl-2-propynyl ethyl malononitrile (92199-63-8)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline; In ethanol; at 20 - 70 ℃; for 4.16667h; Inert atmosphere;

DOI:10.1021/acs.joc.8b01866

Reference yield: 92.0%

3-phenyl-2-propynyl ethyl malononitrile (92199-63-8) + allyl bromide (106-95-6) → ethyl 4-cyano-1-phenyl-6-hepten-1-yne-4-carboxylate (178110-69-5)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Ambient temperature;

DOI:10.1021/ja990682u

Reference yield: 60.0%

3-phenyl-2-propynyl ethyl malononitrile (92199-63-8) → 2-amino-5-benzylthiophene-3-carboxylic acid ethyl ester (216686-60-1)

Guidance literature:

With tetraphosphorus decasulfide; In ethanol; at 20 - 80 ℃;

DOI:10.1021/acs.joc.8b01866

upstream raw materials:

Phenylpropargyl aldehyde

ethyl 2-cyanoacetate

Downstream raw materials:

ethyl 4-cyano-1-phenyl-6-hepten-1-yne-4-carboxylate

2-amino-5-benzylthiophene-3-carboxylic acid ethyl ester