cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

Base Information

Chemical Name:cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one
CAS No.:129152-04-1
Molecular Formula:C₁₇H₁₇NO₂S
Molecular Weight:299.393
Hs Code.:

Synonyms:cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

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Chemical Property of cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

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Technology Process of cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

There total 6 articles about cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 129152-03-0
1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-3-methyl-4-oxo-1,5-benzothiazepine-3-carboxylic acid

: 129152-04-1
cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

Guidance literature:: With toluene-4-sulfonic acid; In dimethyl sulfoxide; at 75 ℃; for 2h;
DOI:10.1021/jo00308a013

Reference yield:

: 21118-89-8
2-<(4-methoxyphenyl)methyl>-2-methylpropanedioic acid, dimethyl ester

: 129152-04-1
cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / N-bromosuccinimide, azobis(isobutrylnitrile) / CCl₄ / 3 h / Irradiation

2: 1) NaH / 1) DMF, 30 min, 2) r.t., overnight

3: 58 percent / NaH / paraffin; dimethylsulfoxide / 16 h

4: 86.7 percent / KOH / methanol / 24 h / Heating

5: 57 percent / p-TsOH*H₂O / dimethylsulfoxide / 2 h / 75 °C

With potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; toluene-4-sulfonic acid; In methanol; tetrachloromethane; dimethyl sulfoxide; paraffin;
DOI:10.1021/jo00308a013

Reference yield:

: 129152-00-7
2--2-methylpropanedioic acid, dimethyl ester

: 129152-04-1
cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH / 1) DMF, 30 min, 2) r.t., overnight

2: 58 percent / NaH / paraffin; dimethylsulfoxide / 16 h

3: 86.7 percent / KOH / methanol / 24 h / Heating

4: 57 percent / p-TsOH*H₂O / dimethylsulfoxide / 2 h / 75 °C

With potassium hydroxide; sodium hydride; toluene-4-sulfonic acid; In methanol; dimethyl sulfoxide; paraffin;
DOI:10.1021/jo00308a013