(4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

Base Information

Chemical Name:(4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one
CAS No.:1421697-16-6
Molecular Formula:C₂₆H₂₄N₂O₃S₂
Molecular Weight:476.62
Hs Code.:

Synonyms:(4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

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Chemical Property of (4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

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Technology Process of (4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

There total 13 articles about (4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

: 874-83-9,33603-63-3
(E)-4-(2-thienyl)but-3-en-2-one

: 145865-96-9
4,9-dihydro-9-(p-toluenesulfonyl)-3H-pyrido-<3,4-b>indole

: 1421697-00-8
(4S,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

: 1421697-16-6
(4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

Guidance literature:: With (S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N-benzhydryl-N,3,3-trimethylbutanamide; acetic acid; In toluene; at 4 ℃; for 60h; Reagent/catalyst; Time; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja310718f

Reference yield:

: 869096-24-2
9-tolylsulfonyl-4,9-dihydro-3H-β-carboline

: 874-83-9,33603-63-3
(E)-4-(2-thienyl)but-3-en-2-one

: (4S,12bR)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

: 1421697-00-8
(4S,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

: 1421697-16-6
(4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

Guidance literature:: 9-tolylsulfonyl-4,9-dihydro-3H-β-carboline; (E)-4-(2-thienyl)but-3-en-2-one; With tris(triphenylphosphine)ruthenium(II) chloride; (S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N-benzhydryl-N,3,3-trimethylbutanamide; acetic acid; In toluene; at 0 - 20 ℃; for 0.166667h;

With tert.-butylhydroperoxide; In decane; toluene; at 0 ℃; for 60.75h; Overall yield = 48 %; enantioselective reaction;
DOI:10.3390/molecules23092228

Reference yield:

: 874-83-9,33603-63-3
(E)-4-(2-thienyl)but-3-en-2-one

: 145865-96-9
4,9-dihydro-9-(p-toluenesulfonyl)-3H-pyrido-<3,4-b>indole

: (4R,12bR)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

: 1421697-00-8
(4S,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

: 1421697-16-6
(4R,12bS)-4-(thiophen-2-yl)-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one

Guidance literature:: With (2S)-2-({[(1R,2R)-2-aminocyclohexyl]carbamothioyl}amino)-N-benzyl-N,3,3-trimethylbutanamide; acetic acid; In toluene; at 4 ℃; for 52h; Reagent/catalyst; Time; Overall yield = > 99 %; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja310718f