[1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

Base Information

Chemical Name:[1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone
CAS No.:1401618-94-7
Molecular Formula:C₃₁H₃₄FN₃O
Molecular Weight:483.629
Hs Code.:

Synonyms:[1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

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Chemical Property of [1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

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Technology Process of [1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

There total 5 articles about [1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 3261-62-9
2-(p-tolyl)ethylamine

: 1401619-23-5
1-(1-(4-fluorobenzyl)-1H-indole-2-carbonyl)piperidine-4-carbaldehyde

: 1401618-94-7
[1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

Guidance literature:: 2-(p-tolyl)ethylamine; 1-(1-(4-fluorobenzyl)-1H-indole-2-carbonyl)piperidine-4-carbaldehyde; In tetrahydrofuran; at 20 ℃; for 10h;

With sodium cyanoborohydride; acetic acid; In ethanol; for 14h;

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1401618-94-7
[1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 60 °C

2.1: sodium hydroxide / ethanol / 3 h / 50 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C

3.2: 22 h / 20 °C

4.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

4.2: 0.5 h

5.1: tetrahydrofuran / 10 h / 20 °C

5.2: 14 h

With oxalyl dichloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 1401618-94-7
[1-(4-fluorobenzyl)-1H-indol-2-yl](4-{[(4-methylphenylethyl)amino]methyl}piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 60 °C

2.1: sodium hydroxide / ethanol / 3 h / 50 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C

3.2: 22 h / 20 °C

4.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

4.2: 0.5 h

5.1: tetrahydrofuran / 10 h / 20 °C

5.2: 14 h

With oxalyl dichloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;