(1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine

Base Information

• Chemical Name: (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine
• CAS No.: 1374787-82-2
• Molecular Formula: C₃₈H₄₂N₂O₂
• Molecular Weight: 558.764
• Mol file: 1374787-82-2.mol

Synonyms:(1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine

Chemical Property of (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine

There total 3 articles about (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H42N2 + formyl acetic anhydride (2258-42-6) → (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine (1374787-82-2)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2012.02.015

Reference yield:

3’,5'-dimethyl-[1,1’]-biphenyl-2-carbaldehyde (445262-63-5) → (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine (1374787-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: amberlyst 15 / toluene / 12 h / Molecular sieve; Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol / 20 h / 0 - 20 °C

3: dichloromethane / 24 h / 0 - 20 °C

With sodium tetrahydroborate; In methanol; dichloromethane; toluene;

DOI:10.1016/j.tetasy.2012.02.015

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → (1R,2R)-N,N'-bisformyl-N,N'-bis[2-(3,5-dimethylphenyl)-benzyl]-1,2-cyclohexanediamine (1374787-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: amberlyst 15 / toluene / 12 h / Molecular sieve; Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol / 20 h / 0 - 20 °C

3: dichloromethane / 24 h / 0 - 20 °C

With sodium tetrahydroborate; In methanol; dichloromethane; toluene;

DOI:10.1016/j.tetasy.2012.02.015

upstream raw materials:

3’,5'-dimethyl-[1,1’]-biphenyl-2-carbaldehyde

formyl acetic anhydride

(1R,2R)-1,2-diaminocyclohexane

Refernces