(2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate
CAS No.:1443036-62-1
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:(2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

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Chemical Property of (2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

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Technology Process of (2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

There total 3 articles about (2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 102-96-5
(2-nitroethenyl)benzene

: 4-Methyl-2-{[1-phenyl-meth-(Z)-ylidene]-amino}-pentanoic acid methyl ester

: (2S,3S,4S,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

: 1443036-62-1
(2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); triethylamine; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine; In toluene; at 25 ℃; for 17h; Reagent/catalyst; Inert atmosphere;
DOI:10.1055/s-0034-1380158

Reference yield: 21.0%

: 102-96-5
(2-nitroethenyl)benzene

: 4-Methyl-2-{[1-phenyl-meth-(Z)-ylidene]-amino}-pentanoic acid methyl ester

: 1443036-62-1
(2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

: methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

Guidance literature:: With silver benzoate; triethylamine; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine; In toluene; at 20 - 30 ℃; stereoselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201400563

Reference yield:

: 75691-28-0
methyl (S)-2-(benzylideneamino)-4-methylpentanoate

: 102-96-5
(2-nitroethenyl)benzene

: 1443036-62-1
(2S,3R,4R,5S)-methyl 2-isobutyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); triethylamine; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine; In toluene; at 20 - 30 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201500160