2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione

Base Information

• Chemical Name: 2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione
• CAS No.: 155373-84-5
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.239
• Mol file: 155373-84-5.mol

Synonyms:2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione

Chemical Property of 2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione

There total 1 articles about 2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-3,10dione (103201-08-7) → 2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione (155373-84-5,2254419-02-6)

Guidance literature:

With sodium azide; sulfuric acid; In chloroform; at 0 ℃; for 3h;

DOI:10.1002/jhet.5570310116

Reference yield: 88.0%

2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione (155373-84-5,2254419-02-6) → 2-oxo-5-hydroxymethyl-1-(2-aminophenylmethyl)pyrrolidine

Guidance literature:

With methanol; sodium tetrahydroborate; In tert-butyl alcohol; for 3h; Heating;

DOI:10.1002/jhet.5570310116

Reference yield:

2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine-3,11-dione (155373-84-5,2254419-02-6) → 2-oxo-5-acetyloxymethyl-1-(2-acetylaminophenylmethyl)pyrrolidine

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / sodium borohydride, methanol / 2-methyl-propan-2-ol / 3 h / Heating

2: 89 percent / 20 h / Ambient temperature

With methanol; sodium tetrahydroborate; In tert-butyl alcohol;

DOI:10.1002/jhet.5570310116

upstream raw materials:

1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-3,10dione