Technology Process of (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride
There total 7 articles about (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium tri-t-butoxyaluminum hydride;
In
tetrahydrofuran; tert-butyl methyl ether;
at -5 - 2 ℃;
for 12h;
DOI:10.1021/ol302262q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; sodium t-butanolate / toluene / 4 h / 95 °C / Large scale
2: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; tert-butyl methyl ether / 12 h / -5 - 2 °C
With
palladium diacetate; lithium tri-t-butoxyaluminum hydride; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate;
In
tetrahydrofuran; tert-butyl methyl ether; toluene;
DOI:10.1021/ol302262q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
2: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; sodium t-butanolate / toluene / 4 h / 95 °C / Large scale
3: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; tert-butyl methyl ether / 12 h / -5 - 2 °C
With
palladium diacetate; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; toluene;
DOI:10.1021/ol302262q
![(6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one](/Databaselist/images/loading.webp)
