N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

Base Information

Chemical Name:N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide
CAS No.:171779-76-3
Molecular Formula:C₂₃H₂₉NO₄Si
Molecular Weight:411.573
Hs Code.:

Synonyms:N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

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Chemical Property of N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

Chemical Property:

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Technology Process of N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

There total 5 articles about N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzimidic acid ethyl ester

: 171779-76-3
N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 0 - 20 ℃; for 12h;
DOI:10.1248/cpb.43.1604

Reference yield:

: 82735-27-1
6,7-dimethoxy-3-trichloromethyl-phthalide

: 171779-76-3
N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Zn, CH₃COOH / tetrahydrofuran / 2 h / 60 °C

2: 77 percent / DEPC, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

3: 92 percent / CH₂Cl₂ / 10 h / 0 - 60 °C

4: 1.) n-BuLi / 1.) Et₂O, -10 deg C, 1 h, 2.) Et₂O, from -50 deg C to RT, 1 h

5: 97 percent / TMSCl, NaI / acetonitrile / 12 h / 0 - 20 °C

With n-butyllithium; chloro-trimethyl-silane; acetic acid; triethylamine; diethyl dicarbonate; sodium iodide; zinc; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1248/cpb.43.1604

Reference yield:

: 171779-77-4
2-(2,2-dichlorovinyl)-5,6-dimethoxybenzoic acid

: 171779-76-3
N-(2-Benzyloxy-ethyl)-2,3-dimethoxy-6-trimethylsilanylethynyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / DEPC, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

2: 92 percent / CH₂Cl₂ / 10 h / 0 - 60 °C

3: 1.) n-BuLi / 1.) Et₂O, -10 deg C, 1 h, 2.) Et₂O, from -50 deg C to RT, 1 h

4: 97 percent / TMSCl, NaI / acetonitrile / 12 h / 0 - 20 °C

With n-butyllithium; chloro-trimethyl-silane; triethylamine; diethyl dicarbonate; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1248/cpb.43.1604