(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate

Base Information

• Chemical Name: (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate
• CAS No.: 912807-27-3
• Molecular Formula: C₁₂H₈Cl₃F₆NO
• Molecular Weight: 402.551
• Mol file: 912807-27-3.mol

Synonyms:(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate

Chemical Property of (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate

There total 1 articles about (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol (368-63-8,68120-60-5,127852-28-2) + trichloroacetonitrile (545-06-2) → (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate (912807-27-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In n-heptane; dichloromethane; at 20 - 27 ℃; for 6h;

Reference yield:

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate (912807-27-3) + triethylamine (121-44-8) + methyl (1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate (190269-75-1) → (1R,2R,3S)-3[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluorophenyl)cyclopentane-1-carboxylic acid triethylamine salt

Guidance literature:

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate; methyl (1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate; tetrafluoroboric acid; In n-heptane; dichloromethane; at -8 ℃; for 23h;

With sodium hydroxide; water; In isopropyl alcohol; at 40 ℃; for 1.5h;

triethylamine; With hydrogenchloride; more than 3 stages;

Reference yield:

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethanimidate (912807-27-3) + methyl (1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate (190269-75-1) → (1R,2R,3S)-3[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluorophenyl)cyclopentane-1-carboxylic acid methyl ester (190271-63-7) + (1R,2R,3S)-3[(S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluorophenyl)cyclopentane-1-carboxylic acid methyl ester

Guidance literature:

With tetrafluoroboric acid; In n-heptane; 1,2-dichloro-ethane; at -15 - 20 ℃; Title compound not separated from byproducts;

DOI:10.1021/jo061268x

upstream raw materials:

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

trichloroacetonitrile

Downstream raw materials:

(7R,8S)-8-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-7-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]decane

(1R,2R,3S)-3[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-2-(4-fluorophenyl)cyclopentane-1-carboxylic acid methyl ester