4-(3-Methylphenyl)-5-(2-methyl-4-pyridyl)-2-[4-(methylthio)phenyl]-1,3-thiazole

Base Information

Chemical Name:4-(3-Methylphenyl)-5-(2-methyl-4-pyridyl)-2-[4-(methylthio)phenyl]-1,3-thiazole
CAS No.:365428-74-6
Molecular Formula:C₂₃H₂₀N₂S₂
Molecular Weight:388.557
Hs Code.:
DSSTox Substance ID:DTXSID50436092
Wikidata:Q82251296

Synonyms:4-(3-METHYLPHENYL)-5-(2-METHYL-4-PYRIDYL)-2-[4-(METHYLTHIO)PHENYL]-1,3-THIAZOLE;365428-74-6;SCHEMBL3887579;DTXSID50436092;BMRNMQNHGZILHO-UHFFFAOYSA-N

Suppliers and Price of 4-(3-Methylphenyl)-5-(2-methyl-4-pyridyl)-2-[4-(methylthio)phenyl]-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-Methylphenyl)-5-(2-methyl-4-pyridyl)-2-[4-(methylthio)phenyl]-1,3-thiazole

Chemical Property:

XLogP3:6.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:388.10679099
Heavy Atom Count:27
Complexity:465

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)C2=C(SC(=N2)C3=CC=C(C=C3)SC)C4=CC(=NC=C4)C

Technology Process of 4-(3-Methylphenyl)-5-(2-methyl-4-pyridyl)-2-[4-(methylthio)phenyl]-1,3-thiazole

There total 5 articles about 4-(3-Methylphenyl)-5-(2-methyl-4-pyridyl)-2-[4-(methylthio)phenyl]-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2-bromo-1-(3-methylphenyl)-2-(2-methyl-4-pyridyl)ethanone hydrobromide

: 53550-91-7
4-(methylsulfanyl)benzenecarbothioamide

: 365428-74-6
2-methyl-4-[4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl]pyridine

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm050165o

Reference yield:

: 325770-44-3
1-(3-methylphenyl)-2-(2-methyl-4-pyridyl)ethanone

: 365428-74-6
2-methyl-4-[4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Br₂; AcOH / 3 h / 80 °C

2: 91 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 21384-43-0
1-(3-methylbenzoyl)-2-methylaziridine

: 365428-74-6
2-methyl-4-[4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -10 °C

1.2: 91 percent / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 66 percent / Br₂; AcOH / 3 h / 80 °C

3.1: 91 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o