2-nitro-3,4,5-trimethoxybenzoyl chloride

Base Information

• Chemical Name: 2-nitro-3,4,5-trimethoxybenzoyl chloride
• CAS No.: 50425-23-5
• Molecular Formula: C₁₀H₁₀ClNO₆
• Molecular Weight: 275.645
• Mol file: 50425-23-5.mol

Synonyms:2-nitro-3,4,5-trimethoxybenzoyl chloride

Chemical Property of 2-nitro-3,4,5-trimethoxybenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-3,4,5-trimethoxybenzoyl chloride

There total 4 articles about 2-nitro-3,4,5-trimethoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5-trimethoxy-2-nitrobenzoic acid (66907-52-6) → 2-nitro-3,4,5-trimethoxybenzoyl chloride (50425-23-5)

Guidance literature:

With thionyl chloride;

Reference yield:

3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester (5081-42-5) → 2-nitro-3,4,5-trimethoxybenzoyl chloride (50425-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 3 h / 20 °C

1.2: 0 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; potassium hydroxide; In methanol; dichloromethane;

DOI:10.1002/chem.201003366

Reference yield:

3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) → 2-nitro-3,4,5-trimethoxybenzoyl chloride (50425-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / acetic acid / 10 - 30 °C

2: sodium hydroxide / ethanol / 2 h / 45 - 50 °C

3: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / 60 °C

With thionyl chloride; nitric acid; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane; acetic acid;

DOI:10.1016/j.bmcl.2016.03.081

upstream raw materials:

3,4,5-trimethoxy-2-nitrobenzoic acid

Eudesmic acid

3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester

3,4,5-trimethoxybenzoic acid methyl ester

Downstream raw materials:

2-cyano-3-oxo-3-(3,4,5-trimethoxy-2-nitro-phenyl)-propionic acid ethyl ester

3-oxo-2-(3,4,5-trimethoxy-2-nitro-benzoyl)-butyric acid ethyl ester

2-nitro-3,4,5-trimethoxyaniline

N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4,5-trimethoxy-2-nitro-benzamide