(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

Base Information

Chemical Name:(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one
CAS No.:852244-95-2
Molecular Formula:C₅₁H₆₄O₇Si
Molecular Weight:817.15
Hs Code.:

Synonyms:(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

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Chemical Property of (2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

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Technology Process of (2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

There total 10 articles about (2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 852244-94-1
(S)-5-Benzyloxy-4-(4-methoxy-benzyloxy)-pentanoic acid methoxy-methyl-amide

: 852244-93-0
tert-Butyl-[(2S,3S)-6-iodo-3-(4-methoxy-benzyloxy)-2-methyl-hexyloxy]-diphenyl-silane

: 852244-95-2
(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

Guidance literature:: tert-Butyl-[(2S,3S)-6-iodo-3-(4-methoxy-benzyloxy)-2-methyl-hexyloxy]-diphenyl-silane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - 0 ℃; for 1.16667h;

(S)-5-Benzyloxy-4-(4-methoxy-benzyloxy)-pentanoic acid methoxy-methyl-amide; In diethyl ether; pentane; at 0 ℃; for 3h;
DOI:10.1021/ol0504291

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 852244-95-2
(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / Ag₂O

2.1: AlMe₃ / CH₂Cl₂; hexane / 0.33 h / 0 °C

3.1: 1.14 g / camphorsulfonic acid / CH₂Cl₂ / 20 °C

4.1: tert-butyllithium / pentane; diethyl ether / 1.17 h / -78 - 0 °C

4.2: 72 percent / pentane; diethyl ether / 3 h / 0 °C

With camphor-10-sulfonic acid; trimethylaluminum; tert.-butyl lithium; silver(l) oxide; In diethyl ether; hexane; dichloromethane; pentane;
DOI:10.1021/ol0504291

Reference yield:

: 852245-14-8
(S)-5-Benzyloxy-4-hydroxy-pentanoic acid methoxy-methyl-amide

: 852244-95-2
(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.14 g / camphorsulfonic acid / CH₂Cl₂ / 20 °C

2.1: tert-butyllithium / pentane; diethyl ether / 1.17 h / -78 - 0 °C

2.2: 72 percent / pentane; diethyl ether / 3 h / 0 °C

With camphor-10-sulfonic acid; tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol0504291