Zgwatinib

Base Information

Chemical Name:Zgwatinib
CAS No.:1268264-10-3
Molecular Formula:C₂₂H₂₂F₃N₅O₂
Molecular Weight:445.444
Hs Code.:

Synonyms:Zgwatinib

Suppliers and Price of Zgwatinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Zgwatinib
5mg
$ 440.00

Total 2 raw suppliers

Chemical Property of Zgwatinib

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Zgwatinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Zgwatinib is a novel, selective c-MET inhibitor, blocking c-MET dependent neoplastic effects and exerting antitumor activity.

Technology Process of Zgwatinib

There total 13 articles about Zgwatinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1332492-87-1
3-(4-methylpiperazin-1-yl)-5-bromo-7-trifluoromethylquinoline

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 1268264-10-3
Zgwatinib

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c1ob05830d

Reference yield:

: 1268264-45-4
C₂₂H₂₀F₃N₅O₂

: 1268264-10-3
Zgwatinib

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm101340q

Reference yield:

: 955978-78-6
2-methyl-1,3-dinitro-5-(trifluoromethyl)benzene

: 1268264-10-3
Zgwatinib

Guidance literature:: Multi-step reaction with 6 steps

1.1: diammonium sulfide / ethanol / 8.5 h / Reflux; Inert atmosphere

2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 100 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 16 h / 135 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: iron; ammonium chloride / ethanol; water / Inert atmosphere; Reflux

5.1: sodium hydroxide / ethanol / 1 h / 78 °C / Inert atmosphere

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere

With diammonium sulfide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen bromide; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide dimethyl acetal; sodium hydroxide; sodium nitrite; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5.1: Friedlaender synthesis;
DOI:10.1039/c1ob05830d