[(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

Base Information

Chemical Name:[(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol
CAS No.:118138-48-0
Molecular Formula:C₂₁H₂₅NO₆
Molecular Weight:387.433
Hs Code.:

Synonyms:[(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

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Chemical Property of [(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

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Technology Process of [(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

There total 14 articles about [(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 128049-98-9
[(S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,8,9-tetrahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

: 118138-48-0
[(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

Guidance literature:: With aluminium hydride; In tetrahydrofuran; for 2h; -30 deg C to room t.;
DOI:10.1016/S0040-4039(01)80681-X

Reference yield: 85.0%

: 118068-13-6
(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxylic acid methyl ester

: 118138-48-0
[(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(01)80681-X

Reference yield:

: (S)-3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2-(3,4,5-trimethoxy-benzoylamino)-propionic acid methyl ester

: 118138-48-0
[(6S,8S)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinolin-8-yl]-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / LiBH₄ / 1,2-dimethoxy-ethane / 10 h / Ambient temperature

2: 95 percent / pyridine / 0.5 h / Ambient temperature

3: POCl₃ / acetonitrile / 18 h / Heating

4: K₂CO₃, MeOH / 0.33 h / Ambient temperature

5: 99 percent / acetonitrile / 48 h / Heating

6: NaBH₄ / methanol / 1 h / -70 °C

7: H₂ / 10 percent Pd/C / methanol / 5 h

With methanol; sodium tetrahydroborate; lithium borohydride; hydrogen; potassium carbonate; trichlorophosphate; palladium on activated charcoal; In pyridine; methanol; 1,2-dimethoxyethane; acetonitrile;
DOI:10.1016/S0040-4039(01)80681-X