6-[(E)-2-(4-nitrophenyl)vinyl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 6-[(E)-2-(4-nitrophenyl)vinyl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine
• CAS No.: 1000867-15-1
• Molecular Formula: C₂₄H₁₇F₃N₆O₃
• Molecular Weight: 494.433

Synonyms:6-[(E)-2-(4-nitrophenyl)vinyl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

Chemical Property of 6-[(E)-2-(4-nitrophenyl)vinyl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 6-[(E)-2-(4-nitrophenyl)vinyl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

There total 2 articles about 6-[(E)-2-(4-nitrophenyl)vinyl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

6-chloro-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (850250-76-9) + 4,4,5,5-tetramethyl-2-[(E)-2-(4-nitrophenyl)ethenyl]-1,3,2-dioxaborolane (149777-86-6) → 6-[(E)-2-(4-nitrophenyl)vinyl]-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (1000867-15-1)

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ISOPROPYLAMIDE; at 130 ℃;

Reference yield:

para-nitrophenyl bromide (586-78-7) → 6-[(E)-2-(4-nitrophenyl)vinyl]-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (1000867-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tributyl-amine; triphenylphosphine / palladium diacetate / toluene / 60 h / 110 °C

1.2: 0.17 h

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ISOPROPYLAMIDE / 130 °C

With tributyl-amine; sodium carbonate; triphenylphosphine; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ISOPROPYLAMIDE; toluene;

Reference yield:

6-[(E)-2-(4-nitrophenyl)vinyl]-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (1000867-15-1) → 6-[(Z)-2-(4-aminophenyl)vinyl]-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine trifluoroacetate + 6-[(E)-2-(4-aminophenyl)vinyl]-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine trifluoroacetate

Guidance literature:

With tin(ll) chloride; In ethanol; at 70 ℃; for 0.5h;

upstream raw materials:

6-chloro-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

4,4,5,5-tetramethyl-2-[(E)-2-(4-nitrophenyl)ethenyl]-1,3,2-dioxaborolane

para-nitrophenyl bromide

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