1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine

Base Information

• Chemical Name: 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine
• CAS No.: 160376-91-0
• Molecular Formula: C₂₆H₂₉F₆NO₃
• Molecular Weight: 517.512
• Mol file: 160376-91-0.mol

Synonyms:1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine

Chemical Property of 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine

There total 5 articles about 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,5-bis(trifluoromethyl)benzyl bromide (32247-96-4) + 1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine (158144-85-5) → 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine (160376-91-0)

Guidance literature:

With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine + 3,5-bis(trifluoromethyl)benzyl bromide (32247-96-4) → butoxycarbonyl-4-phenyl-4-[(3,5-bistrifluoromethyl)benzyl oxymethyl]piperidine + 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine (160376-91-0)

Guidance literature:

In N-methyl-acetamide; hexane; ethyl acetate;

Reference yield:

(4-phenyl-piperidin-4-yl)-methanol (4220-08-0) → 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine (160376-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / tetrahydrofuran; CH₂Cl₂ / 18 h / 25 °C

2: 66 percent / NaH / dimethylformamide / Ambient temperature

With sodium hydroxide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980376b

upstream raw materials:

3,5-bis(trifluoromethyl)benzyl bromide

1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine

(4-phenyl-piperidin-4-yl)-methanol

4-phenyl-piperidine-4-carboxylic acid