4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine

Base Information

• Chemical Name: 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine
• CAS No.: 1430334-15-8
• Molecular Formula: C₁₆H₁₆N₆O₃
• Molecular Weight: 340.341
• Mol file: 1430334-15-8.mol

Synonyms:4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine

Chemical Property of 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine

There total 2 articles about 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.4%

2-chloroethanal (107-20-0) + 4-morpholino-6-(2-nitrobenzyl)-1,3,5-triazin-2-amine (1430334-10-3) → 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine (1430334-15-8)

Guidance literature:

In water; dimethyl sulfoxide; at 120 ℃; for 7h; regioselective reaction;

DOI:10.1016/j.tet.2013.03.039

Reference yield:

moroxydine hydrochloride (3160-91-6,7420-18-0) → 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine (1430334-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.33 h / 70 °C / Microwave irradiation

2: dimethyl sulfoxide; water / 7 h / 120 °C

In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1016/j.tet.2013.03.039

Reference yield: 94.0%

4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine (1430334-15-8) → 4-(4-(2-nitrobenzyl)-3,4-dihydroimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine (1430334-20-5)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; for 20h; Inert atmosphere;

DOI:10.1016/j.tet.2013.03.039

upstream raw materials:

2-chloroethanal

4-morpholino-6-(2-nitrobenzyl)-1,3,5-triazin-2-amine

moroxydine hydrochloride

Downstream raw materials:

4-(4-(2-nitrobenzyl)-3,4-dihydroimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine