(2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

Base Information

Chemical Name:(2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene
CAS No.:332035-53-7
Molecular Formula:C₂₈H₂₈O₂
Molecular Weight:396.529
Hs Code.:

Synonyms:(2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

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Chemical Property of (2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

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Technology Process of (2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

There total 1 articles about (2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 52340-78-0
(R,R)-hydroxybenzoin

: 58812-72-9
4,4-dimethyl-3-(4-methylphenyl)-cyclopent-2-en-1-one

: 332035-53-7
(2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene; for 36h; Heating;
DOI:10.1016/S0957-4166(00)00457-2

Reference yield: 91.0%

: 75-11-6
diiodomethane

: 332035-53-7
(2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

: (4'R,5'R)-2,2-dimethyl-1-p-tolyl-4',5'-diphenylspiro[bicyclo[3.1.0]hexane-4.2'-[1,3]dioxolane]

Guidance literature:: (2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene; With diethylzinc; In hexane; dichloromethane; at 0 ℃; for 0.25h;

diiodomethane; In hexane; dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/S0957-4166(00)00457-2

Reference yield:

: 332035-53-7
(2R,3R)-8,8-dimethyl-2,3-diphenyl-7-p-tolyl-1,4-dioxaspiro[4.4]non-6-ene

: 936723-38-5
(+)-(1R,5R)-4,4-dimethyl-5-p-tolyl-bicyclo[3.1.0]hexan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₂Zn / CH₂Cl₂; hexane / 0.25 h / 0 °C

1.2: 91 percent / CH₂Cl₂; hexane / 2 h / 0 °C

2.1: 10 percent aq. HCl / methanol / 1.5 h / 20 °C

With hydrogenchloride; diethylzinc; In methanol; hexane; dichloromethane;
DOI:10.1016/S0957-4166(00)00457-2