C₁₅H₁₂ClNO₂S₂

Base Information

• Chemical Name: C₁₅H₁₂ClNO₂S₂
• CAS No.: 882280-82-2
• Molecular Formula: C₁₅H₁₂ClNO₂S₂
• Molecular Weight: 337.851
• Mol file: 882280-82-2.mol

Synonyms:C₁₅H₁₂ClNO₂S₂

Chemical Property of C₁₅H₁₂ClNO₂S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₂ClNO₂S₂

There total 4 articles about C₁₅H₁₂ClNO₂S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C17H16ClNO2S2 (882278-95-7) → C15H12ClNO2S2 (882280-82-2)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃;

DOI:10.1021/jm901280q

Reference yield: 78.0%

C16H13ClNO2PolS2 → C15H12ClNO2S2 (882280-82-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h; Wang resin

DOI:10.3109/14756366.2011.643302

Reference yield:

2-(bis(isopropylthio)methylene)malononitrile (1334294-79-9) → C15H12ClNO2S2 (882280-82-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 3 h / Reflux

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 0.17 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 4 h / Reflux

4: sodium hydroxide / ethanol / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; potassium carbonate; sodium hydroxide; copper(ll) bromide; In ethanol; water; toluene; acetonitrile; 2: |Sandmeyer Reaction / 3: |Suzuki-Miyaura Coupling;

DOI:10.3109/14756366.2011.643302

upstream raw materials:

C₁₇H₁₆ClNO₂S₂

2-(bis(isopropylthio)methylene)malononitrile

ethyl 3-amino-4-cyano-5-(isopropylthio)thiophene-2-carboxylate

Downstream raw materials:

4-(4-chlorophenyl)-2-(isopropylthio)thiophene-3-carbonitrile

(R)-methyl 2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoate

N-(adamantan-1-yl)-3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamide

3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)-N-(naphthalen1-yl)thiophene-2-carboxamide